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L’emivita media di eliminazione plasmatica del fluconazolo variava tra le 15 e le 18 ore e il volume di distribuzione dopo somministrazione di dosi multiple è risultato pari a circa 880 ml/kg. The cytoplasm is filled with primary, secondary, and tertiary granules. Based on the study results, these authors recommended that back-up contraception may not be necessary if OCs are used reliably during oral antibiotic use.
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